Related guidance: Depression in adults: treatment and management NICE guideline (NG222 June 2022)

Depression in adults with a chronic physical health problem: recognition and management
Clinical guideline (CG91 October 2009)

Do not routinely offer antidepressant medication as first-line treatment for less severe depression, unless that is the person’s preference. DO NOT INITIATE DOSULEPIN.

Anticholinergic load. Antidepressants, particularly tricyclics have an anticholinergic activity which accumulates with other anticholinergic drugs such as medicines for PD, psychosis, overactive bladder, COPD and N&V. In the elderly this can cause serious physical instability, delirium and cognitive decline.

Almost half of those on long-term antidepressants can stop without relapsing (NIHR March 2022)

Citalopram max dose

Escitalopram max dose